Background: This study was conducted to assess cytokine levels in subjects having community-acquired pneumonia. Material and methods: Pneumonia sufferers had been involved in the investigation. During the hospital stay, serum cytokine concentrations had been assessed, genotyping was carried out, the responsible bacteria were determined, and subjects were watched closely. Results: Individuals having pneumococcal pneumonia had considerably higher blood cytokine concentrations. The beginning of corticosteroid therapy had an independent impact on the decline in cytokine concentrations. Conclusion: Acute phase proteins, such as IL-1RA, IL-6, IL-8, and IL-10, are not genotype-dependent. The type of the causing microbe and the beginning of corticosteroid therapy have an impact on their levels Keywords: cytokine, pneumonia