Background: Background: Peripheral nerve blocks have advantages over general anesthesia as it decreases the need for postoperative analgesia and the incidence of nausea and vomiting, shortens post anaesthesia care unit time and increases patient satisfaction. Supraclavicular Brachial Plexus Block provides anesthesia and analgesia of the upper extremity in the most consistent and efficient manner. Ropivacaine has become a safer substitute for bupivacaine as local anaesthetic for peripheral nerve blocks but to overcome shorter duration and to further improve the duration and quality of analgesia, various adjuvants have been added to the local anesthetics and we studied the effect of dexmedetomidine and fentanyl as adjuvants with ropivacaine. Aim: To compare the effect of dexmedetomidine and fentanyl as an adjuvant to ropivacaine in supraclavicular brachial plexus block in upper limb surgeries. Methods: A total 96 patients were recruited into 3 groups by simple randomization technique: Group RD : 0.5% Ropivacaine with 1mcg/kg Inj.Dexmedetomidine to make 30 ml Group RF : 0.5% Ropivacaine with 1mcg/kg Inj. Fentanyl to make 30 ml Group RC : 0.5% Ropivacaine 30 ml. Results: Onset of motor and sensory blockade was earliest in dexmedetomidine group (11.55±3.19 and 13.42± 4.51 in minutes) followed by fentanyl group (15.16±4.54 and 14.32±5.24 in minutes) and last in control group. In fentanyl group mean duration of motor and sensory block was maximum (13.10±2.56 and 13.42± 4.51 in hours) followed by dexmedetomidine group (12.84±2.45 and 12.10±2.82 in hours) and least in control group. Dexmedetomidine group took more time for first rescue analgesia (16.06±2.28) and had better Visual analogue score (3.90±1.08) as compared to group RF and group RC. Conclusion: We concluded that Dexmedetomidine and Fentanyl in a dose of 1mcg/kg as an additive to 0.5% ropivacaine in a total volume of 30 ml for supraclavicular block for upper limb surgeries quite effacaciously prolongs the duration of blockade and provides better quality of anaesthesia. Dexmedetomidine provides over all better blockade characterstics in terms of onset time, VAS score and time to request for first analgesic postoperatively without causing any major adverse effects. Keywords: Supraclavicular block, Dexmedetomidine, Fentanyl, Ropivacaine, upper limb surgery.