Abstract Issue

Volume 12 Issue 3 ( July-September ) 2023

Original Articles

A study on Seroprevalence of dengue IgM and IgG antibodies in children suffering from febrile illness in correlation with platelet count.
Dr. Udayasri.B, Dr. Bhogadi Sujatha, Dr. Srinivas. N

Background: Dengue is the commonest arboviral infection affecting large group of population every year. Secondary dengue infection is associated with various complications like hypovolumic shock, DIC and DSS. Early detection and prediction of complications will help in appropriate management of the disease. Determination of Dengue IgM and IgG will help in identifying the primary and secondary infections. Current study is aimed to detect dengue IgM and IgG antibodies in febrile illness children. Methodology: A total number of 96 clinically suspected pediatric cases of dengue were included in the study. Serum samples were collected and stored as per protocol. Dengue IgM and IgG antibodies were detected in the serum samples by ELISA using pan bio dengue capture elisa kits. Platelet count of the patients were recorded. Results: Out of 96 samples 62 were positive either for dengue IgM or IgG. In the preset study male preponderance of disease is noted, maximum age group affected is 6-10yrs, common complaint is fever and mayalgia. Out of 62 seropositive cases 35 (56.45%) were primary infections positive only for dengue IgM, 15 (24.19%)were secondary infections positive for both IgM & Ig G and 12(19.35%) were past infections only positive for IgG. Among the 15 secondary dengue infections low platelet count was found in 93% cases, with a significant p-value 0.00467(p<0.05). Conclusion: Detection of Dengue I g M and IgG is very important to know the type of infection and helps in prevention of complications.

 
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