Aim: The objective of this study is to assess the serum electrolyte levels, acid-base balance, and the necessity of non-invasive ventilation in patients experiencing a hypercapnic acute exacerbation of chronic obstructive pulmonary disease. Material and Methods: A prospective and observational study was conducted on a cohort of 100 patients who were admitted to the Department of Pulmonary Medicine due to exacerbation of chronic obstructive pulmonary disease (COPD). Blood investigation were performed. They include arterial blood gases (ABG) and electrolyte levels (Sodium (Na) and potassium (K). Results: The mean potassium of the patients who need medical treatment only was 3.69±0.39 m E q/l and mean Sodium was 137.25±3.96 m E q/l, whereas the mean potassium for the other group was 4.29±0.55 m E q/l and mean Sodium was 135.17±4.17 m E q/l. The mean serum Bicarbonate of the group the need medical treatment only was 23.66±2.33 m Eq /l. The mean serum Bicarbonate of the other group was 29.01±2.11 m E q/l. In table 5, the Sodium and Potassium levels before treatment were 135.17±4.17 and 4.29±0.55 m E q/l, respectively, and mean Sodium and Potassium levels after treatment were 133.33±3.74 and 3.42±0.52 m E q/l, respectively. Conclusion: Noninvasive positive pressure ventilation (NPPV) has the potential to facilitate the effectiveness of alternative treatments in cases of hypercapnic respiratory failure, thereby potentially circumventing the need for endotracheal intubation. While less severe instances of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) typically exhibit reversibility, the presence of more severe respiratory failure is linked to a significant mortality rate and an extended period of disability among those who survive.