Background: Knee joint is a complex joint which includes both tibiofemoral joint and patellofemoral joint. The bony geometry of the tibia and femur contributes to the static stability of the knee joint and is responsible for the normal knee kinematics.The distal extremity of the femur is wider and presents a widely expanded double condyle bearing partly articular surface for transmission of weight to the tibia. Objective: To study morphometric study of distal end femur in the population of central India: comparison with other ethnic groups and it’s clinical implication in knee joint prostheses. Material and Methods: In this Cross-sectional descriptive study, 250 dry human femurs,125 right side and 125 left side, were examined, in the LN Medical College, Bhopal (Madhya Pradesh) region, where the morphology and morphometry of the distal end of femur including bicondylar width, anteroposterior and transverse diameter of medial and lateral condyle and intercondylar width were measured and statistically analyzed. Results: In this study there were no statistically significant parameters between right and left femur. Conclusion: The present study aims to assess different morphometric parameters of distal end of femur, to compile and analyze the results, and formulate a baseline data for future studies with relevance to Indian population. These parameters of the distal end of femur can be used to guide treatment and monitor outcome of total knee replacement surgeries in Indian scenario.