Abstract Issue

Volume 12 Issue 2 ( April- June) 2023

Original Articles

Immunohistochemistry status and clinicomorphological features in breast cancer patients at a Peripheral Cancer Centre
Dr.Amarendra Dharwar,Dr.Gururaj Deshpande,Dr.Vasant Harsoor,Dr.Nandhini

Breast cancer has many clinical and morphological parameters which change the prognosis of these patients like tumor size, lymph node involvement, histological grade of tumor. Oestrogen is a mitogen which shows its effect by binding to its receptor (ER) and is positive seen in 50-80% of breast cancer. A total of 51 consecutive cases done between October 2020 to March 2023 were included in the study. Available data on age, immunohistochemistry, size, grade, lymph node status were retrieved from available records. Grading was done by Nottingham grading system. In this study which included 51 breast cancer cases, 50 were females and 1 male case. Mean age was 48 yrs. Left side breast cancer was slightly more common in our study (54.9%). Infiltrating duct carcinoma was most common histological variant (92.1%) followed by lobular, papillary and medullary variants. Grade 2 was most common (74.5%)-Nottingham grading system. 28 cases (50.9%) belonged to stage II followed by 23 cases of stage III. 32 cases (62.7%) presented with axillary lymph node metastases. In our group of patients we dint find any significant correlation between age of patient and hormonal status on IHC. Also we dint find any association between HER2/neu status and age of the patient. However the incidence of triple negative receptor breast cancer was more in younger age group.

 
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