Introduction: Breast cancer is the most frequent and lethal tumour in women worldwide, with roughly 1.7 million women diagnosed each year and one in every three dying from the disease. Although the incidence of breast cancer is 4-7 times greater in the United States and Europe than elsewhere, global incidence and death are increasing at an alarming rate, and it is anticipated that by 2020, 70% of cases will be in low-income nations. The study's goal is to link Vascular Endothelial Growth Factor (VEGF) expression with ER, PR, Her-2/Neu, and Ki- 67 index expression in cases of invasive breast cancer using immunohistochemistry (IHC). Materials and Methods: FFPE section of 30 cases of HPE confirmed cases of breast malignancy were taken up and subjected to IHC using predetermined markers. Result: The intensity of VEGF immunostaining in malignant breast lesions was evaluated and scoring was done and evaluated as positive(≥3) or negative(˂3). Statistical analysis was performed with Chi-Square test. And significant differences were noted between different variables. Conclusion: Our study showed a statistically significant association between VEGF expression and ER and Her2/neu expression. Also VEGF expression was negatively correlated to Her2/neu expression.