Abstract Issue

Volume 12 Issue 3 ( July-September ) 2023

Original Articles

Preterm labour and fetomaternal outcome in cholestasis of pregnancy in elderly women
Dr. Ruqiya Rashid, Dr. Khushbu Bashir

Background: Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disease seen in pregnanc. Intrahepatic cholestasis of pregnancy (IHCP) is characterized by pruritus of the hand and sole with abnormal liver function test and bile acid metabolism. IHCP occurs in the second and third trimesters of pregnancy and usually resolves after delivery. ICP has been found to be associated with increased risk of preterm delivery, meconium staining of amniotic fluid, fetal bradycardia, fetal distress and fetal demise. Material and mehods: The present prospective observational study was conducted in the Postgraduate Department of Obstetrics and Gynaecology, SKIMS Srinagar Jammu and Kashmir over a period of 18 months and total of 150 patients were enrolled in study. After taking history and examination,baseline investigations were done . Patients diagnosed with cholestasis of pregnancy were followed till delivery and post delivery and preterm births and fe to maternal outcome was assessed. Results: The maternal and foetal outcomes in 150 consecutive women with ICP during the study period were assessed. Majority of womeni,e 98(65.3%) were multigravida.Period of gestation at diagnosis was 28-36+6 weeks in 85(56.6%) of patients and >/= 37 weeks in 65(43.3%) of patients. 48(32%) patients had spontaneous onset of labour and in102(68%) patients labour was induced.86(57.4%) of patients belong to age group of 35-40 years and 64(42.6%) patients belong to age group of 41-45 years. Patients with cholestasis of pregnancy had fetal tachycardia in 46(30.6%) of fetuses,fetal bradycardia in 36(24%) of fetuses, poor varaiability in 9(6%) of fetuses, decelerations in 39(26%) of fetuses and arrhythmia in 20(13.3%) of fetuses. Conclusion: Intrahepatic cholestasis of pregnancy is associated with adverse feto-maternal and the adverse outcome is more common in elderly patents. Itching over whole body was the predominant presenting complaints of cholestasis of pregnancy. Cholestasis in elderly patients was associated with higher rates of LSCS, preterm births, non reassuring fetal heart pattern and higher rates of NICU admissions. By proper antenatal assesement and timely intervention the outcome can be improved to the large extent.

 
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