Abstract Issue

Volume 12 Issue 4 ( October-December ) 2023

Original Articles

Investigation of platelet properties in individuals diagnosed with type 2 diabetes mellitus
Dr. Zia Ur Rehman Khan, Dr. Abhishek Gupta

Aim: Investigation of platelet properties in individuals diagnosed with type 2 diabetes mellitus. Material and methods: This study included total of 100 subjects with 70 diabetic (type 2) patients attending the diabetic clinic and 30 non diabetics (control group). The demographic information and clinical details of the patients were recorded including duration of diabetes, family history of diabetes, hypertension, drug history, special reference to any complications or co morbidities. Result: The average age of the participants was 59.26±12.27 years. The proportion of males and females was equal, with each gender comprising 50% of the total population. Among the observed patients, a majority of 70% were diagnosed with diabetes, while the remaining 30% were found to be non-diabetic. In the present research, the average PCT levels were determined among participants who had complications, yielding a mean value of 0.31±0.09. Conversely, individuals without complications exhibited an average PCT level of 0.29±0.1. The statistical analysis revealed that the connection between PCT and the occurrence of complications was not found to be significant. The mean MPV among individuals who had complications was 13.94±1.37, which was seen to be greater compared to persons without complications (9.92±1.96) and non-diabetic subjects (8.53±1.72). However, the association between PC and HbA1C was found to be not statistically significant (p value>0.05). Conclusion: The majority of patients diagnosed with type II diabetes mellitus have avoidable vascular angiopathies, and timely identification of the gradual activation of coagulation may effectively aid in the management of these vascular disorders. Hence, both MPV and PDW exhibit potential use as prognostic indicators for cardiovascular complications in individuals with diabetes. Both MPV and PDW have the potential to serve as affordable and straightforward laboratory tests for monitoring diabetes mellitus (DM), in addition to HbA1c.

 
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