Background: Lichen planus pigmentosus, an uncommon variant of lichen planus, is an enigma with perplexed treatment. Several treatment modalities has been tried but with variable results. Objectives: The primary objective of the study is to compare the efficacy and safety of 0.1% tacrolimus ointment versus 1% pimecrolimus cream in the treatment of LPP. Method: 60 patients were randomly divided into 2 groups of 30 patients each. Group A was asked to apply 0.1% tacrolimus while Group B was asked to apply 1% pimecrolimus cream twice daily. The results were evaluated on the of physician’s global assessment, patient’s satisfaction score, patient’s global tolerance and coloured photographs. Results: Physician’s assessment and patient’s satisfaction score were comparable and good to moderate in both the groups but were statistically non significant (p > 0.05). Drug tolerability was good to excellent in both the groups. Conclusion: Topical calcineurin inhibitors like tacrolimus and pimecrolimus can be considered as a treatment modality of LPP with greater tolerability and negligible adverse effects as compared to systemic treatment. Furthermore, larger prospective studies are required to investigate their outcomes.