Introduction: Epidural anesthesia is a versatile technique for providing anesthesia andpostoperative analgesia. Contributes to maintenance of hemodynamic stabilityand reduces postoperative stress, improving the patient outcome. Objectives:Levobupivacaine with clonidine and ropivacaine and clonidine were used in lower abdomen and lower limb procedures during epidural anesthesia to compare the onset and duration of sensory and motor blocking. Materials and method:The present study was prospective observational analytical study. This study was conducted from January 2021 to June 2021, the study was done in the R.G. Kar Medical College's Obstetrics and Gynecology, Orthopaedics, and Surgery operation operation theatre. Total 70 patients were included in this study. Result: In our study, out of 70 patients, mean Duration of Surgery was higher in Group-A [97.91428571± 18.35815483] compared to Group-B [95.85714286±21.57359887 (min)] which was not statistically significant (p=0.66). We found that, mean Onset of sensory block was higher in Group-A [18.65714286± 1.433688315] compared to Group-B [16.34285714±0.998317913 (min)] though it was not statistically significant (p=0.989). It was found that, mean Onset of motor block was lower in Group-B [18.91429± 2.019651] compared to Group-A [22.45714±0.781079 (min)] but this was not statistically significant (p=0.622). We found that, mean Duration of Sensory Block was higher in Group-A [186.9428571± 6.949155078] compared to Group-B [163±7.970534 (min)] though it was not statistically significant (p=4.39). Our study showed that, mean Duration of Motor Block was higher in Group-A [203.5714286± 6.92092188] compared to Group-B [179.4286±7.252933 (min)] though it was not statistically significant (p=2.31). Our study showed that, slightly higher number of patients had ASA1 in Group-B [24 (23.5)] compared to Group-B [23 (23.5)] but this was notstatistically significant (p=.799133). In our study. Majority number of patients had MPG 1 in GROUP A [28] compared to GROUP B [27] which was notstatistically significant (p=.419316). Conclusion:We conclude that, the onset is slower and duration of sensory and motor blockade is longer in levobupivacaine with clonidine compared to ropivacaine with clonidine for epidural anesthesia in lower limb and lower abdominal surgeries, it is not statistically significant.