Introduction: The drugs commonly employed for the induction of abortion and the management of incomplete abortion or intrauterine foetal demise (IUFD) are typically a combination of mifepristone and misoprostol, or alternatively, misoprostol alone. The current study has been conducted with the aim of comparing theefficacyofmifepristonefollowedbymisoprostol with misoprostol alone for management of early pregnancy failure. Methodology: A Randomized controlled study was conducted in the department of Obstetrics and Gynaecology, Rohilkhand Medical College and Hospital, Bareilly from 1stNovember2019 to 31st October 2020. among 102 women having symptoms and signs suggestive of early pregnancy failure before 12weeks of gestation. Statistical analysis was done using SPSS software (version 23) and the result were calculated in percentage and compared using chisquare test. A p-value of less than 0.05 was considered significant. Observations: In the present study, in mifepristone followed by misoprostol group 86.27% patient had complete abortion where as among patients in misoprostol only group, 54.90%of them had complete abortion. In group A, merely 9.8% patients requiredblood transfusion whereas in group B, 29.41% patients needed blood transfusion. Conclusion: We conclude that the utilization of a combination of mifepristone and misoprostol for the medical management of early pregnancy failure is considered a safe and non-invasive alternative to surgical evacuation and is better than misoprostol alone. Consequently, patients experiencing early pregnancy failure are more likely to accept or tolerate the treatment.