Aim and objectives: The aim of the study was to assess the Neutrophil Lymphocyte Ratio as a markerof Endothelial Dysfunction and Insulin Resistance in patients with Type 2 Diabetes. Materials and method: The present study was a hospital based cross-sectional study carried out in the department of clinical medicine.Neutrophil and lymphocyte ratio (N/L ratio) was calculated by doing complete blood count. Then the ratio of the absolute neutrophil count to absolute lymphocyte count will be calculated.Insulin resistance was assessed by HOMA-IR. Endothelial dysfunction was detected non-invasively by ultrasonographic analysis of brachial artery-flow mediated vasodilatation (FMD). Results: There were 58.0% males and 42.0% females mean age of 49.88±10.91 (range = 32.00-78.00) years. There was a significantly positive correlation of NL ratio with Fasting blood sugar, HbA1C%, Ultrasound guided Flow mediated vasodilatation (FMD), Serum Insulin and HOMA-IR2. Conclusion: NLR deterioration is associated with glycaemic disorder, which increases the importance of haemogram in diabetic patients. Improvement of NLR after glycaemic regulation has suggested that this parameter may be more useful in demonstrating glycaemic regulation rather than complications.