Background: Diabetic foot is one the commonly faced surgical conditions by surgeons. It is one of the major causes for morbidity in diabetic patients. Inspite of various types of dressings available, choosing an appropriate dressing is a challenging aspect in the management of diabetic foot. Topical insulin causes rapid wound remodelling in non healing ulcers and its topical application in wound healing needs further study. Methodology: Our study is a randomized prospective study was conducted in the Department of Surgery, Teaching Hospital attached to Kodagu Institute of Medical Sciences, Madikeri on 50 patients with non healing chronic diabetic ulcer during the period of November 2022 to October 2023. The patients are randomly divided into two groups study and control group (Study – Insulin; Control – Normal saline). Wound measurement and culture growth was taken on day 1 and end of 14th day. Mean reduction in ulcer area and culture growth at the end of 14 days was noted. Results: In our study, we have observed that mean reduction in ulcer size in insulin (study) (8643.68±2348.95 mm2) is statistically significant compared to normal saline group (control) (2067.45±464.88 mm2) and there is 56.8±2.3% reduction in size in insulin group compared to 17.7±1.4% which is statistically significant. Conclusions: Tropical insulin has an angiogenic, fibroblast growth favouring and antibacterial property which canbe used in faster healing of chronic diabetic ulcers as topical agent and thereby reducing its systemic side effects.