Background: COPD is primarily caused by long-term exposure to irritants, usually cigarette smoke, but can also be triggered by exposure to other harmful particles or gases in the environment. The present study was conducted to assess epidemiological and clinico-radiological profile of COPD patients. Materials & Methods: 80 COPD patients of both genders were selected. Parameters such as history of presenting symptoms, radiological presentation was recorded. Severity of symptoms as perceived by the patient was measured using Modified Medical Research Council grades (mMRC) and COPD Assessment Test (CAT). The modified medical research council scale of dyspnea to assess the severity of dyspnea was recorded. Results Mean age of the patients of the present study was 57.66 ± 13.57 years. 86.3 percent of the patients were males while the remaining 13.8 percent were females. Breathlessness was found to be present in all patients (100%). Cough and chest tightness was found to be present in 95 percent and 30 percent of the patients respectively. Clubbing was found to be present in 46.25 percent of the patients. The maximum patients were in 2nd grade of clubbing i.e. 22.5%. Grade 1 and grade 3 was present in 15% and 8.8% of patients respectively. Cyanosis and Pedal edema was found to be present in 5 percent and 31.3 percent of the patients respectively. Emphysematous changes were seen in all the patients (100 %). Cardiomegaly was seen in 28.7%, Tubular heart seen in 37.5%., Hilar prominence in 22.5%, Pruning of blood vessels at periphery in 22.5% and bullae seen in 10% of the patients67.5% of patients belong to COPD-C with history of smoking. 20 % of patients belongs to COPD-I with history of occupational exposure and in 32.5 % of patients belongs to COPD-I with history of occupational exposure. Conclusion: Our research contributes to raising awareness of the value of quitting smoking, the necessity of early COPD diagnosis, and the requirement for ongoing care.