Abstract Issue

Volume 3 Issue 5 ( October-December ) 2014

Original Articles

A Cross-Sectional Study of Cutaneous Manifestations of Polycystic Ovarian Syndrome
Dr.Nehal Shah, Dr.NileshGadhvi

Background and Aim: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, affecting 5–10% of reproductive aged women. The dermatologic manifestations of hyperandrogenism, chiefly hirsutism, acne vulgaris, androgenic alopecia, and acanthosisnigricans, are among the cardinal manifestations of PCOS. The aim of this study was to determine the pattern and frequency of different cutaneous manifestations in PCOS patients and to correlate them with the hormonal profile.Material and Methods: A cross sectional study with a total 160 patients with features suggestive of PCOS attending department of dermatology, venereology and leprosy and department of obstetrics and gynecologies in a tertiary care Hospital of Gujarat were screened. Pregnant women and diagnosed cases of any other endocrine disorder were excluded. Hirsutism was assessed using Ferriman-Gallwey score and AGA according to Ludwig’s classification. Serum hormonal profile including FSH, LH, prolactin, testosterone (free), DHEAS, TSH, FBS, fasting insulin were done. Insulin resistance was determined by calculating HOMA-IR score.Results: Mean age of incidence was 24.40 years.Ultrasonological evidence of PCOS changes was present in 90.62% patients. Patients with hirsutism (n=144) were found to have raised serum prolactin levels in 20.83% patients with a p value of 0.02. No statistically significant association was seen between hirsutism and other hormone levels.Conclusion: Polycystic ovarian syndrome (PCOS) is one of the most frequently encountered endocrine disorders in women of reproductive age group. The evaluation should include detailed menstrual history, information about the onset and duration of symptoms suggestive of hyperandrogenism and family history of PCOS and metabolic diseases.

 
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