Aim: To asses smoking alcoholism and NSAIDS intake as a independent risk factor for peptic ulcer perforation. Material and methods: An analytical investigation was undertaken at B.R.D Medical College, Gorakhpur to asses smoking alcoholism and NSAIDS intake as a independent risk factor for peptic ulcer perforation. Based on the findings, ethical clearance was recommended. In this investigation, the patients were categorised into two categories. This research comprised patients from group 1 who had perforation peritonitis caused by peptic ulcer perforation. The patients included in group 2 had an endoscopic diagnosis of peptic ulcer disease. Results: In this study , people of more than 15 were taken in to study, in which 41 - 50 year age people were more common followed by >60 years. In this study Male were mostly affected as compared to Female, mostly patient were Male. In this study smoking and alcohol have been found to be a major risk factor for perforation, where smoking is found to be 63.33% and alcohol 50%. In this study , patient with History of NSAIDS intake for unspecified pain or chronic illness was 56.67%. Most common site of perforation is the distal part of the stomach, in this study pre pyloric site was more common (86.67%) as compared to pyloric part (13.33%). Conclusion: Perforated peptic ulcer is often seen in individuals within the age range of 41-50 years. The delayed onset of the illness is associated with patients who come from distant regions without adequate healthcare facilities and health education. Consequently, these patients often arrive to the hospital at an advanced stage of the condition.