Background: A diabetic foot ulcer is an open sore or wound that occurs on the feet of individuals with diabetes. The present study was conducted to assess the efficiency of the management of diabetic foot ulcers with PRP and conventional dressing. Materials & Methods: 54 patients with diabetic foot ulcers of both genders were divided into 2 groups of 27 each. Group I received homologous platelet dressings, and group II patients received conventional moist wound dressings. Parameters such as skin grafting, necrotic tissue, duration of hospital stay, number of wound debridement, and wound dressing etc. were compared. Results: There were 17 males and 10 females in group I and 18 males and 9 females in group II. The mean duration of hospital stay was 16.2 days in group I and 39.1 days in group II. The mean wound debridement days was 3.8 in group I and 18.2 in group II. The mean wound dressing days was 7.2 in group I and 42.5 in group II. The skin grafting was required in 5 in group I and 13 patients in group II. The difference was significant (P< 0.05). Conclusion: Platelet dressing patients were found to be superior to those treated with conventional wound dressing in terms of split skin grafting, duration of hospital stay, number of wound debridement, and duration of wound debridement.