Introduction: Respiratory distress remains one of the most common cause of neonatal death in thedeveloping world . The respiratory support in the form of Continuous Positive Airway Pressure (CPAP) ormechanical ventilation is provided to the neonates during distress. Bubble CPAP is an important, simple,non-invasive, and cost effective treatment modality for respiratory distress in neonate. Objective: To as certain the outcome of neonates with respiratory distress on bubble CPAP and identify risk factors associated with its failure. Methods: This observational study was conducted in SNCU of the tertiarycare center of central India, over the duration of 18 months enrolling 215 neonates .All the neonates who had SAS/DOWNES≥4 were included. Data was compiled using MS EXCEL and analyzed using IBMSPSS20. Result: The Gestational age and Birth weight was 34-36weeks and 1.5-2.0kg respectively. The most common cause of starting BCPAP was RDS 121(56.3%) followed by, Birth asphyxia70 (32.6%),MAS 25(11.6%) and TTNB15(7.0%). The common complication on BCPAP was Nasal damage55(25.6%).Overall failure rate was 114 (53%). Eighty three ( 72.8%) failure was seen in Respiratory Distress Syndrome group followed byPerinatal asphyxia23( 20.1%), Meconium Aspiration Syndrome 16( 14%) and Transient Tachypnea of Newborn 2( 1.7%). All babies who failed on BCPAPwereputon mechanical ventilation .CPAPFailurerate washigherinneonates who hadsepsis andshockConclusion: Indigenous Bubble CPAP may be considered as a primary mode of respiratory support inmild respiratory distress in resource poor settings. It is an effective way of improving oxygenation inneonateswithmild respiratory distress.