Background: Portal vein thrombosis in the general population is a rare event, but it occurs relatively frequently in patients with cirrhosis and its prevalence increases with severity of the disease. In this study we are studying the prevalence of PVT symptoms, its clinical relevance. Materials & Methods: 100 patients of chronic liver disease were subjected to abdominal ultrasonography, portal vein colour doppler studies and coagulation profile. All patients were subjected to fasting glucose, liver function test and the coagulation profile (Prothrombin time, INR). Results: In male participants age group 36-45 years have the highest number of participants; age group 15-25 years has the lowest number of participants while in female participants age group 46-55 years and 26-35 years have the highest and lowest participants respectively. Hepatitis B (20%) was the most common etiology of chronic liver diseases followed by others (18%) and Alcohol (15%). Hepatitis C contributes as an etiology in 4% of chronic liver disease patients. Ascites was the most common clinical feature in the study subjects (60%) followed by Splenomegaly (35%). Encephalopathy and Hematemesis both constitute 29% in participants. 89 participants have above-normal splenic diameter while 29 participants have above-normal portal vein diameter. Portal vein thrombosis was found in 9 participants while 6 of them have portal vein obstruction. According to Child Pugh class majority of participants were in class A (42%) and lowest numbers are in class B (28%). All 9 patients of portal vein thrombosis have splenomegaly and ascites while 7 patients also have encephalopathy and 6 have hematemesis along with portal vein thrombosis. Hematemesis encephalopathy, splenomegaly, ascites are significantly associated with PVT group when compared with non PVT p values of 0.001,0.002,0.001 and 0.002 respectively. Conclusion: Portal vein thrombosis is considered to be a frequent complication of liver cirrhosis. Portal vein thrombosis could worsen the rate of hepatic decompensation and survival of cirrhosis. The prognostic value of PVT in cirrhosis remains a gray zone.