Background: The upper gastrointestinal tract disorders are one of the most commonly encountered problems with high degree of morbidity and mortality. A wide variety of infections, inflammations, autoimmune and neoplastic conditions may occur. The aims of this study is to determine the spectrum of the histopathological lesions of upper GIT biopsies and their correlation with endoscopic findings. Materials and Methods: It iscross sectional, descriptive and observational studydone in the department of pathology at Maharishi Markandeshwar Medical College and Hospital, Kumarhatti, Solan, Himachal Pradesh from January 2022 to December 2022 on 191 upper GIT endoscopic biopsies. Results: Study observes that common age of presentation was 30-50 years with male to female ratio of 1.4:1. Majority of the biopsies were from stomach 160(83.76%), followed by duodenum 20(10.47%), esophagus10(5.2%)and GE junction1(0.52%).In stomach, non-neoplastic lesions were common predominantly comprising of chronic gastritis (82.5%) with Helicobacter pylori positivity seen in 61 cases (46.21%). The most common encountered endoscopic findings in chronic gastritis were hyperemia, erythemia and erosion of mucosa. Among duodenal and esophageal biopsies, chronic nonspecific inflammatory pathology with endoscopic finding of multiple superficial erosions were common. Conclusion: Endoscopy in combination with biopsy for Histopathological examination plays an important role in the early diagnosis of GI tract lesions and also provide an opportunity for a broad range of treatment options as well as potential for possible cure.