Background:Phantom limb pain in the amputated limbis often accompanied by significant suffering. The present study was conducted to evaluate phantom limb pain in diabetic and non-diabetic leg amputees. Materials & Methods:52diabetic patients underwent leg amputation of both genders. Patients were divided into 2 groups. Group I were diabetic patients underwent leg amputation and group II had non- diabetic (control) patients underwent leg amputation. Parameters such as prevalence, intensity and characteristics of phantom limb pain was recorded. Results: Group I had 20 males and 14 females and group II had 18 males and 16 females. Amputation level was transtibial seen in 6 and 7, partial foot in 5 and 2, knee disarticulation in 4 and 6 patients, transfemoral in 10 and 11, hip disarticulation in 9 and 8 patients in group I and II respectively. The difference was significant (P< 0.05). The mean experience phantom limb pain (PLP) was seen in 32 and 30, experience phantom sensations (PS) was seen in 27 and 25, phantom limb pain intensity on VAS was 3.8 and 3.2. Dull ache pain in 12 and 13, sharp/stabbing pain was seen in 16 and 11, burning pain in 2 and 3, shooting/electric pain in 3 and 5, and cramping pain in 1 and 2 patients in group I and II respectively. Conclusion: Non- diabetic subjects had less phantom limb pain in compared to diabetic patients.