Abstract Issue

Volume 12 Issue 4 ( October-December ) 2023

Original Articles

Evaluating the relationship between HbA1c levels, lipid profile, and TSH levels in subjects with type 2 diabetes
Dr. Kuldeep Singhal, Dr. Gaurav Bhashker, Dr. Pradeep Kumar

Background: Previous literature established a link between diabetic status and thyroid dysfunction with data reporting a higher incidence of thyroid dysfunction in subjects with type 2 diabetes compared to type 1 diabetes. However, the literature data establishing this correlation are scarce. Aims: The present study assessed the levels of HbA1c (glycosylated hemoglobin) and TSH (thyroid stimulating hormone) in the subjects with type 2 diabetes and to assess the correlation between HbA1c levels and thyroid hormone levels and in HbA1c levels and lipid type in type 2 diabetics. Methods: The present retrospective study assessed 200 subjects from both male and female genders with type 2 diabetes mellitus. In all the subjects, laboratory data were retrieved for biochemical tests along with demographic data from the records of the institute. The data extracted were statistically analyzed to get the results. Results: The study results showed normal levels of T4 and TSH in study subjects with respective values of 14.1 pmol/L and 4.5 mIU/L respectively and an increased value of HbA1c with 8.4% in the study subjects. A non-significant relationship was seen in HbA1c and thyroxin with p=0.83 and a weak positive correlation in TSH and HbA1c with p=0.02. A weak positive correlation was also seen among HbA1c and low-density lipoprotein and total cholesterol with respective p-values of 0.002 and 0.001. Conclusion: The present study concludes that an increase in blood glucose levels can stimulate the anterior pituitary for increased TSH secretion. However, no direct correlation exists between the rate of thyroxin secretion and increased glycemic index. Also, a weak correlation exists between some lipid markers and blood glucose levels.

 
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