Introduction:Thyroid hormone plays crucial roles in adult brain function, and it is widely acknowledged that hypothyroidism is linked with neuropsychiatric symptoms encompassing emotional, cognitive, and mood changes. Subclinical hypothyroidism (SCH) is characterized by elevated thyroid-stimulating hormone (TSH) levels within normal free triiodothyronine (FT3) and free thyroxine (FT4) ranges. Patients with primary hypothyroidism have demonstrated an elevated risk of fractures, although there is conflicting data regarding changes in bone mineral density (BMD) within this group.This study aimed to explore the relationship between anxiety, depression, BMD, and SCH. Materials and Methods: Anxiety, depression and BMD (DEXA scan) were evaluated in 145 SCH cases over a one-year period. Participants were sourced from patients undergoing thyroid function testsat BirsaMunda Government Medical College and Hospital on OPD and IPD patients by Departments of Medicine, Orthopedics and Psychiatry collectively. Inclusion criteria encompassed individuals aged 20-50 years with TSH levels between 5.5-10 mU/L and normal FT3 and FT4 levels. Exclusion criteria comprised individuals already on thyroxine supplementation, those with pre-existing psychological conditions, substance abuse, chronic diseases, or neurological disorders. Results: The study revealed mild anxiety and moderate depression among SCH cases. BMD was decreased but not significantly. Statistical analysis showed a significant correlation between anxiety and SCH and between depression and SCH. Conclusion: Among SCH cases, mild anxiety and moderate depression were observed, with BMD generally remaining intact. The study underscores a noteworthy association between anxiety/depression and SCH, independent of age, sex, and body mass index.