Background: Hypersensitivity pneumonitis (HP), also called extrinsic allergic alveolitis, is a respiratory syndrome involving the lung parenchyma and specifically the alveoli, terminal bronchioli, and alveolar interstitium, due to a delayed allergic reaction. Hence; the present study was conducted for assessing the clinical and pathological profile of 50 patients with Hypersensitivity pneumonitis Materials & Methods: A total of 50 patients were enrolled. Complete demographic and clinical details of all the patients were obtained. HP suspected patients underwent a symptom screening with special exposure history, general and respiratory physical examination, chest X-ray, routine blood tests, sputum examination, connective tissue serology complete pulmonary function test (PFT). Only confirmed cases of HP were included as study group. A Performa was made and detailed clinical and pathological findings of all the painters were recorded. Bronchoalveolar lavage (BAL) findings were recorded separately. Histopathologic findings were analyzed separately. All the results were recorded in Microsoft excel sheet and were subjected to statistical analysis using SPSS software. Results: On histopathological analysis, BAL lymphocytosis > 30% was seen in 46 percent of the patients while Broncho-centric inflammation with ill-defined granuloma, Broncho-centric inflammation with lymphocytic inflammation and Ill-defined granuloma with lymphocytic inflammation was seem om 26 percent, 26 percent and 18 percent of the patients respectively. Conclusion: It is believed that HP is an occupational illness. In all suspected instances, a lung biopsy and bronchoscopy with BAL should be performed to confirm the diagnosis.