Aims and Objectives: To assess the efficacy of Negative-pressure wound therapy dressing using a locally constructed Negative-pressure wound therapy device and comparing it with regular gauze dressings for large wounds. Materials and Methods: A prospective observational study was done ,80 patients with non-healing leg ulcers were recruited from the Department of General Surgery, Government Wenlock Hospital, Mangalore Karnataka, India during the period of March 2021 to March 2022. All patients with Chronic leg ulcers i.e. defect in the skin below the level of knee persisting for more than six weeks and showing no tendency to heal after three or more months were included in study.Patients with osteomyelitis, peripheral vascular disease, or malignancy were excluded. Of the 80 patients, 40 patients received NPWT using Ryles tube dressings, 40 patients were treated with regular conventional dressings. Results: The use of vacuum therapy in large wounds resulted in improved wound healing as evidenced by faster healing, shorter hospital stay and improved graft uptake compared to conventional dressing. Conclusion: Ryles tube technique NPWT dressing is a safe and economical method for treatment of large wounds.