Background: Cervical cancer remains the second most common malignancy in women worldwide. The present study was conducted to assess importance of hemoglobin levels before and during chemoradiotherapy in locally advanced carcinoma cervix. Materials & Methods: The present study was conducted among 60 patients with carcinoma of the cervix. Pretreatment hemoglobin levels at presentation and during concurrent chemo radiotherapy were studied. Blood transfusions and the time point when transfusions were given were recorded. The level of significance for all tests was P < 0.05. Results: In the present study, 63.33% patients had Hb >10g/dl and 36.66% had <10g/dl. In our study, 36.66% were diagnosed with anemia before the start of radiation therapy, 16.66% (10 patients) developed anemia during radiation therapy. All 22 patients with pretreatment anemia were transfused with PRBC before RT and 10 patients were transfused during Radiation therapy (RT).. The mean baseline hemoglobin in our study in Stage IIB, IIIA, IIIB, and IV A was 11.45, 10.34, 11.12, and 10.6 respectively. Out of the 22 patients who received transfusion before RT, 3 patients had complete response. Out of the 10 patients who received transfusion during radiation, 4 had complete response. Conclusion: The present study concluded that Pretreatment hemoglobin and hemoglobin levels during radiation therapy were prognostic factors as Hb levels decreased during Radiotherapy.