Background: Diabetic foot is a serious and debilitating complication of diabetes that affects millions of individuals worldwide. It is a chronic condition that requires continuous management to prevent morbidity and mortality. Aims and Objective: The present study was aimed to calculate prevalence of diabetic foot and study of biochemical profile of diabetic food in patients with diabetes. Material and Methods: This study was carried in department of surgery, Muzaffarnagar medical college, Muzaffarnagar from June 2022 to February 2023. This study includes 66 diabetic patients who came diabetic follow-up clinic. Results: This study was enrolled 380 patients with diabetes who came for follow-up. In this study, the prevalence of diabetic foot ulcer patients among diabetes was 14.21%. The mean age of the studied participants were 53 with 62.96% male and 37.04% female. 57.41% patient had diabetic retinopathy changes, 37.08% had the history of HTN, 20.37% patients had vascular disease, 59.26% had smoking history, 27.78% subjects on insulin, 46.30% on oral hypoglycemic drug and 25.92% patients were on both insulin and oral hypoglycemic drug. Conclusion: The prevalence of diabetic foot ulcer among diabetic patients is 14.21% Subjects with higher BMI (overweight and obesity), types of diabetes, neuropathy, and foot self-care practice were factors significantly associated with diabetic foot ulcer.