Aim: The aim of this study is to compare the platelet levels before and after surgery in patients diagnosed with benign and malignant neoplasms. Material and methods: The study sample consisted of patients who had received a histopathological confirmation of either a benign or malignant neoplasm. The participants in the study cohort were instructed to undergo a platelet count examination 2-3 days prior to the surgical procedure and on the 7th day following the surgery. Throughout the duration of the study, a consistent Cell Counter was employed for all patients in order to mitigate any potential discrepancies in platelet counts resulting from technical factors. Results: The average preoperative platelet count for patients with malignant neoplasms was 301.58±19.85 K/µl, while the average postoperative platelet count was 192.86±12.58 K/µl [Table 3]. In contrast, for patients with benign neoplasms, the average preoperative platelet count was 211.29±22.58 K/µl, and the average postoperative platelet count was 271.58±15.96 K/µl. In Table 3, it is observed that there is a statistically significant difference (P < 0.0001) between the pre-operative and post-operative levels in both cases. Conclusion: Platelets play a significant role in the pathophysiology of cancer. The present study provides further support for the existing research findings regarding the interaction between tumor cells and platelets.