Background: The present study was conducted for comparing two different doses of intravenous dexmedetomidine on intubating conditions during nasotracheal intubation. Materials & methods: A total of 40 patients were enrolled (20 patients in each group). Every patient received medication as IV infusion for 15 mins according to the randomization which was done earlier using computer generated random numbers: Group A: received an infusion of 1.5mcg/kg dexmedetomidine diluted in 50 ml saline, and Group B: received an infusion of 0.5mcg/kg dexmedetomidine diluted in 50 ml saline. Awake fibreoptic intubation was done after standardized airway preparation in both the groups. Five-point fiberoptic intubation comfort score was used. A post-operative visit was undertaken the day after operation during which the level of recall, adverse events and satisfaction scores (1 = excellent, 2 = good, 3 = fair, 4 = poor) were also be assessed. All the results were recorded in Microsoft excel sheet and were analysed using SPSS software. Results: While comparing the five-point fiberoptic intubation comfort score in between the two study groups, non-significant results were obtained.While comparing statistically the post-op anxiety score, significant better results were seen among patients of group A while poor results were seen among patients of group A. Non-significant results were obtained while comparing the incidence of hoarseness and sore throat among the patients of all the three study groups. While comparing statistically the patient satisfaction score, significantly better results were seen among patients of group B while poor results were seen among patients of group A. Conclusion: Lower plasma concentrations of dexmedetomidine may be used to provide sedation and mild analgesia while preserving memory and cardiovascular and respiratory functions.