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Volume 12 Issue 3 ( July-September ) 2023

Original Articles

Addition of neostigmine on dose requirement of ropivacaine 0.1% in labouring patients receiving lumbar epidural analgesia: Hemodynamic changes
Dr.Archana Dande, Dr.Anjana K, Dr.Balasubramanya H,Dr.BalaBhaskar S

Epidurally administered Ropivacaine is effective in providing analgesia during labour. It is recommended to administer 10-20 ml bolus of Ropivacaine 0.2% with intermittent 20-30 mg top up injections or a continuous epidural infusion of Ropivacaine 0.2% (6-10 ml/hr.) for labour analgesia. The analgesic efficacy of Ropivacaine is almost similar to or slightly less than bupivacaine. The difference in incidences of operative deliveries when Ropivacaine was compared with bupivacaine was also not found significant. Patients were randomized into two groups using computer generated random numbers: GROUP A: Received 0.1% Ropivacaine with fentanyl 2µg/ml in 10 ml total volume. GROUP B: Received 0.1% Ropivacaine with fentanyl 2µg/ml and neostigmine 500µg in 10 ml total volume. Baseline hemodynamic parameters likematernal heart rate, oxygen saturation, ECG, non-invasive blood pressure, wererecorded. The mean maternal heart rate at 45min interval in group A was 88.56 (± SD 3.20) and in group B was 92.32 (±SD 5.00), which was statistically significant (p value 0.003).The mean maternal heart rate at 180min interval was 87.32 (±SD 2.66) in group A and 90.16 (±SD 5.54) in group B, which was statistically significant (p value 0.025).

 
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