Background: There is limited evidence on how intensive multifactorial treatment (IT) improves outcomes of diabetes when initiated in the lead time between detection by screening and diagnosis in routine clinical practice. Objective: We examined the effects of early detection and IT of type 2 diabetes in primary care on the prevalence of diabetic peripheral neuropathy (DPN) and peripheral arterial disease (PAD) 6 years later in a pragmatic, cluster-randomized parallel group trial. Methods: We screened diabetic patients and divided our study into two phases. All the diabetic patients were grouped into two to receive either routin e care and intensive treatment. In the second phase we followed-up all patients and observed the diabetes related parameters and assessed the effect on peripheral artery disease and peripheral diabetic neuropathy. Results: The mean duration of follow-up was 2.8 years for the control group and 3.5 years for the intensive treatment group. However, a modest reduction in HbA1c levels was seen in the intervention group. Both groups saw a notable decrease in systolic and diastolic blood pressure, as well as total cholesterol levels, which was consistent across the groups. During the follow-up period, there was a general rise in the percentage of individuals who utilised medicine. The effect on PAD and DPN was in favour of intensive therapy. Conclusion: In a population characterised by the detection of type 2 diabetes by screening, it was shown that the implementation of intensive therapy subsequent to screening resulted in a statistically significant variation in the occurrence of DPN and PAD three years following the first diagnosis.