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Volume 12 Issue 3 ( July-September ) 2023

Original Articles

To determine serum ferritin as prognostic marker in intracranial hemorrhage: A prospective study
Sidhartha SankarBhuyan, Bikash Chandra Nanda, Nayan Kumar Patel, Chakradhar Majhi

Background: Monitoring of ferritin levels plays a crucial role in the management of various disorders and the evaluation of therapy efficacy. In addition, serum ferritin's predictive value extends beyond disease progression. Aim: The present study aim is to determine the serum ferritin levels in acute hemorrhagic stroke patients, between different prognostic groups, and also to correlate the levels with severity of acute hemorrhagic stroke. Materials & methods: This study was conducted in VIMSAR, Burla from December 2018 to November 2020. This was a hospital based observational study. A group of 60 subjects participated in this study. Clinical evaluation was carried out noting vital parameters, clinical signs of focal neurological deficit and signs of increased intracranial tension. Other systems were also examined to find significant comorbidities. All patients were treated according to the established guidelines at the time of study. Results: In the good prognosis group, fifty percent of patients had their serum ferritin values in the range of 200 – 300 ng/ml. Five patients had their serum ferritin value more than 400 ng / ml. The mean serum ferritin value was 290.7 ng/ml (SD 98.06). This difference is statistically significant (P < 0.05). On comparison, serum ferritin values are found to be statistically high in mortality group followed by bad prognostic group. 7 patients (77.7%) in the good prognostic group had their ferritin value less than 200 ng/ml. The mean serum ferritin value was 144. 7 ng/ml (SD 90.95). This is statistically significant with P < 0.05. Among dead, the majority (61.9%) have serum ferritin in the range of 300-400 ng/ml, followed by 23.8% have value more than 400 ng/ml. The mean serum ferritin value was 355.4 ng/ml (SD 82.8). This difference is statistically significant (P< 0.05). Conclusions: we conclude that the baseline serum ferritin can be used as an independent prognostic marker. The increased body iron stores as measured by ferritin is associated with clinical deterioration.

 
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