Background: Studies in many countries revealed deficiencies in “Nurses” knowledge about the inhalation therapy in patients of Bronchial Asthma and Chronic obstructive pulmonary disease. Inhaler therapy is preferred treatment of these diseases and Metered Dose Inhaler are most commonly used in the treatment. Aim and Objectives: To determine knowledge and practice of‘Nurses’ regarding inhaler technique. Method: It is a cross sectional study. The questionnaire was designed which consisted of 20 questions for assessing the knowledge and practice related inhalational therapy. Results: A total of 800 respondents completed the questionnaire. 800 participants were given questionnaire for the study. Out of which, 24 questionnaires were only partially filled and were thus excluded from the data analysis. Total 776questionnaires were analysed. 576(73.8%) participants have heard the term inhalational therapy .596(76.8 %) of nurse swere of the opinion that inhalers are habit forming. According to651 (83.89 %) nurses inhaler causes weight gain and causes stunted growth. 526(67.78%) nurses responded that it is advised to start inhalation prior to pressing thecanister. According to 451(58.11%) nurses spacer should not be held between the teeth. 381(49.09%) participants knew that we should shake the Metered Dose Inhaler (MDI) before use.325(41.88%) nurses responded that dry-powder inhaler (DPI) should also be shaken before use. Conclusion: The study reveals the poor status of knowledge of MDI and DPI technique among Nurses. Special educational programmes are required to address the treatment failure due to inadequate knowledge among ‘Nurses’.