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Volume 11 Issue 4 (October-December) 2022

Original Articles

To compare the efficacy of oral furosemidemetolazone versus oral furosemidespironolactone combination therapy in management of edema in nephrotic syndrome
Dr. Akshay Shukla, Dr. Mahendra Kumar Pandey, Dr. Shashi Vinod, Dr. Madhulika Tiwari

Background &Method: The aim of the study is to compare the efficacy of oral furosemide- metolazone versus oral furosemide- spironolactone combination therapy in management of edema in nephrotic syndrome. All children of age group 6 months -14 years attending the out-patient department (OPD) and In-patient department (IPD) in pediatric department with complaint of generalized swelling and decreased urine output were admitted and diagnosed as case of nephrotic syndrome. Result: Mean input and urinary output over 5 days in both group A and B patients. The mean urine output in patients of group B was higher than group A with values being statistically significant for day 5 (p-value 0.04). Thus concluding that Diuretic action of Group B (frusemide- metolazone) was better than group A (frusemide-spironolactone). Conclusion: We conducted a study to compare the efficacy of frusemide- spironolactone and frusemide– metolazone combination in patients admitted in Pediatric department as a case of nephrotic syndrome having edema. Our study showed that group B had higher mean weight loss as compared to group A specially on days 4 and 5 of the diuretic therapy. Thus showing that frusemide metolazone combination had better diuretic action than frusemide spironolactone. On comparing the urine output we found that Group B had more urine output as compared to Group A particularly in days 4 and 5 of therapy. Study Designed: Comparative Study

 
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