Background: Every year globally, four million neonates die in the first 4 weeks of life. The present study was conducted to assess neonatal outcome of the patients admitted in NICU. Materials & Methods: 80 neonates of both genderswas enrolled. Parameters such as mode of delivery, birth weight, gestational age, indication for admission etc. was recorded. Laboratory investigations such as C-reactive protein (CRP), complete blood count (CBC), positive blood culture and cerebrospinal fluid (CSF) examination was carried out. Outcome after hospitalization in NICU was recorded. Results: Out of 80 patients, males were 45 and females were 35. The etiology found to be hypoglycemia in 7, neonatal hyperbilirubinemia in 15, cardiac anomaly in 8, congenital anomaly in 4, sepsis in 16, respiratory distress in 20 and birth asphyxia in 10 patients. The difference was significant (P< 0.05). Gestational age was <34weeks present in 25, 34–36.6weeks in 35 and >37weeks in 20. Birth weight was 1500grams seen in 31, 1500-2500grams in 39 and >2500grams in 10 patients. The mode of delivery was vaginal in 22 and caesarean in 52. The difference was significant (P< 0.05). Conclusion: Sepsis, respiratory distress, birth asphyxia, hypoglycemia, neonatal hyperbilirubinemia, cardiac abnormalities, and congenital anomaly were the most frequent reasons for NICU hospitalization.