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Volume 12 Issue 3 ( July-September ) 2023

Case Reports

Biomarker Profile Alteration in a Case of High-Grade Breast Carcinoma: Tumour Heterogeneity, Metaplasia or Chemotherapeutic Effect?
Dr. Vaishali Yadav, Dr. Kavita Gaur, Dr. Kiran Agrawal

Background: Neo-adjuvant chemotherapy is employed for patients with locally advanced breast carcinoma and in cases of metastatic or inoperable breast carcinoma to reduce tumor size and subsequently improve breast-conserving surgery rates. Biomarker studies performed on excisional specimens may be discordant with those performed on trucut biopsy, moreso after neo-adjuvant chemotherapy. There is paucity of data in the literature on whether the primary tumour characteristics, hormone receptors and HER2 expression change as a result of chemotherapy. The present case report shows biomarker profile alteration in a case of high-grade breast carcinoma.

 
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