Background: Prostate lesions are a common pathology encountered in clinical practice, often necessitating Transurethral Resection of the Prostate (TURP) for diagnostic and therapeutic purposes. However, there is limited information on the histopathological spectrum of lesions encountered in TURP chips. This study aims to comprehensively analyze the histopathological findings in TURP chips, shedding light on the diversity and prevalence of prostate lesions. Methodology: A retrospective analysis was conducted on TURP chips obtained from 200 patients. Data collection included patient demographics, clinical parameters, and histopathological examination of the chips. Inclusion criteria encompassed all patients who underwent TURP, while exclusion criteria excluded patients with incomplete or missing data. Results: The study cohort comprised 200 patients with a mean age of 65 years. Histopathological analysis identified a diverse spectrum of lesions, with benign lesions being the most common (60%), followed by pre-malignant lesions (20%) and malignant lesions (20%). Among the benign lesions, prostatic hyperplasia, inflammation, and atrophy were the predominant findings. Additionally, pre-malignant lesions were characterized by the presence of prostatic intraepithelial neoplasia (PIN), while malignant lesions predominantly consisted of adenocarcinoma. The distribution of these lesions exhibited variations across different age groups and clinical parameters. Conclusion: This study provides valuable insights into the histopathological spectrum of prostate lesions in TURP chips, emphasizing the need for comprehensive evaluation and clinical vigilance. Understanding the prevalence and distribution of these lesions is crucial for guiding clinical practice and future research in the field.