In essence, oro-dental pharmacology delves into the realm of medications employed for addressing oral and dental ailments. Consequently, grasping the pivotal concepts of pharmacokinetics and pharmacodynamics becomes imperative for comprehending how drugs behave within the body. Pharmacokinetics involves the absorption, distribution, metabolism, and excretion of drugs, while pharmacodynamics explores the correlation between drug concentration and its impact on the body. The absorption of oral cavity-administered drugs hinges on factors like the drug's physico-chemical properties, formulation, and the oral health of the patient. The effectiveness of a drug in managing oral and dental diseases relies on its capacity to reach the intended site and elicit the desired response. Hence, a drug's efficacy and safety are contingent on its pharmacodynamic traits, encompassing potency, selectivity, and duration of action.In the realm of dental therapy and oral surgery, a profound understanding of pharmacokinetics and pharmacodynamics proves indispensable. Strategic drug and dosage selection can significantly enhance treatment outcomes while mitigating the risk of adverse effects. Achieving this necessitates a holistic grasp of drug action principles, patient-specific factors, and the nature of the specific disease or condition under treatment.