BackgroundAcne vulgaris is a multifactorial, chronic inflammatory disease of the pilosebaceous unit. It is caused due to follicular hyperkeratinisation, hormonal influence on increased sebum production & composition, inflammation, interaction of Propionibacterium acnes with innate immune system. Metabolic syndrome is a multisystem disorder that increases the risk of diabetes mellitus, stroke and cardiovascular disease. In the pathogenesis of metabolic syndrome and acne, inflammatory markers like TNF-α, IL-1, IL-6, IL-8, IL-17 and oxidative stress have shown a possible correlation. Objective To study the association between acne vulgaris and metabolic syndrome. Methods Total of 55 patients, attending dermatology out-patient department at KIMS, hubballi and clinically diagnosed with acne vulgaris were subjected to detailed history taking and their waist circumference, blood pressure, fasting lipids (mainly triglycerides and HDL) and fasting blood glucose tests were done after obtaining written informed consent. Clearance from institutional ethics committee is obtained. Patient who refused to give consent for the study and having dermatological disorder such as psoriasis, rosacea, hidradenitis suppurativa etc. were excluded from the study. Results On clinical examination, grade 2 was the most prevalent grade of acne. We observed an increased incidence of abnormal waist circumference, triglyceride, HDL, and fasting blood glucose. An increased occurrence of metabolic syndrome was observed. Conclusion Patients with acne vulgaris have a greater chance of developing metabolic syndrome. Hence, an in-depth examination of clinical, anthropometric and biochemical parameters that may lead to the development of metabolic syndrome is necessary in order to prevent occurrence of cardiovascular accidents.