Background:This study explores the prevalence of depression and anxiety in individuals with Type 2 Diabetes Mellitus (DM), Systemic Hypertension (SHT), and Chronic Obstructive Lung Disease (COPD). Examining 180 patients, we aimed to compare depression and anxiety levels among these groups, shedding light on the intricate relationship between chronic illnesses and mental health. Methods:A cross-sectional design involved sociodemographic data analysis, employing chi-square tests to assess associations. Depression and anxiety prevalence were determined using established criteria.Result:The study uncovered significant mental health challenges among patients with chronic illnesses. In the DM group, 23.3% faced depression, with 21 males affected compared to 14 females (p<0.14). Anxiety afflicted 21.7%, 5% severely. COPD patients reported depression (28.4%) and anxiety (23.4%), indicating substantial psychological burdens. These findings underscore the need for integrated healthcare strategies addressing both physical and mental aspects in chronic disease management.Conclusion:This study emphasizes the considerable mental health burden in DM and COPD, urging holistic care approaches. While illuminating, limitations warrant cautious interpretation, emphasizing the need for expansive, longitudinal studies