Malignant mesothelioma commonly arises from the pleura and peritoneal cavity but rarely can arise from the greater omentum. The presentation is non specific and generally have a poor prognosis with high possibility of metastasis. Only a few cases of malignant mesothelioma of greater omentum have been reported.Here we present a case of middle aged male presenting withpain abdomen and gross ascites, later on diagnosed as Primary Omental Mesothelioma .A 50 year old male presented with pain abdomen and gross ascites .CECT Abdomen showed omental nodules.Biopsy and IHC confirmed Malignant mesothelioma of Omentum.He was treated with 6 cycles of pemetrexed carboplatin and is now on maintenance pemetrexed . PETCT post treatment showed near complete resolution of omental nodules with no ascites.He is now on regular follow up.Our case presentation conclude that Omentum can be a primary site of Malignant mesothelioma .Diagnosis of such cases need careful examination and Histopathology with Immunohistochemistry as well as Radiological imaging. In case of metastasis, Systemic Chemotherapy and Palliation play a major role in increasing the Overall Survival.