Introduction: Gallstone disease produces diverse histopathological changes in gallbladder mucosa-namely, acute inflammation, chronic Inflammation, granulomatous inflammation, hyperplasia, cholesterosis, metaplasia, dysplasia and neoplasia. Hence; the present study conducted for assessing histopathologic changes occurring in gallbladder mucosa in gall stone patients. Materials & Methods: A total of 200 gall stone patients who underwent laparoscopic cholecystectomy were enrolled. All the specimens of gallbladder mucosa were processed by routine tissue processing. After completion of processing, sectioning of the specimens was done under microtome followed by staining with H and E stain. After staining, all the final diagnosis was made based on histopathologic examination. Results: Chronic cholecystitis was the most common diagnosis found to be present in 91 percent of the patients. Both invasive and Pre-invasive diagnosis was found to be present in 4.5 percent of the patients each. Invasive lesions were more commonly encountered in patients with multiple gallstones. Invasive lesions were more commonly associated with larger stones while cholecystitis was more commonly associated with smaller stone size. Conclusion: A significant relationship exists between pathologic changes of gall bladder mucosa and gall stone parameters. However; further studies are recommended.