Introduction: Open reduction and internal fixation (ORIF) with volar locking plate has now become the treatment of choice in intra-articular distal end radius fractures during the past decades. The present study was conducted to assess the clinical outcome after 6 months. Aims and objective:To study the outcome of intra-articular distal end radius fracture treated with open reduction and internal fixation (ORIF) with volar locking plate. Methodology: Present prospective study was conducted for patients with intra-articular distal radius fracture attending to the department of Orthopedics, who underwent open reduction and internal fixation with volar plates. The clinical outcome was assessed by measuring the range of dorsiflexion, palmar flexion, radial deviation, ulnar deviation, pronation and supination at 6 weeks, 3 months, and 6 months and compared with the normal side at 6 months. Results and Discussion:Achievements of different movements in operated hand as compared to the normal side were dorsiflexion (90% of normal), palmar flexion (92%), radial deviation (89%), ulnar deviation (85%), pronation (96%) and supination (91%). Conclusion: ORIF with volar locking plate and early mobilization in patients with intra-articular fractures of distal end radius shows excellent functional outcome in terms of the range of movements at the wrist and were able to achieve was more than 90% movements compared to the normal side.