Background and aims: Periodontal disease is the commonestdental infectious diseases affecting up-to 90% of adults. The oral cavity, particularly periodontal tissues is affected by the use of external hormones particularly by oral contraceptives. Hormonal contraceptives are agents that are based on the effects of gestational hormones and they prevent ovulation.This study evaluates the effect of contraceptives drugs on health of periodontal tissues and levels of IL-6 in gingival crevicular fluid. Materials and methods: Thirty patients who had not used oral contraceptives (control) and thirty patients using oral contraceptives (case) were examined clinically and their medical history, dosage and usage of oral contraceptives were recorded. Periodontal indices such as bleeding on probing, plaque index, probing pocket depth, clinical attachment loss and levels of IL-6 in gingival crevicular fluid were measured. Student’s t-test and Mann-Whitney test were used to analyze data. Results: Mann-Whitney test showed a statistically significant difference in the mean of clinical attachment levelsin the case and control groups (P<0.05) and highly statistically significant difference in the mean of IL-6 levels (P-0.001), probing pocket depth (P<0.05) and radiographic bone loss between the case and control groups (P<0.05). Conclusion: It seems that use of oral contraceptives may affect the periodontal health status of patients, leading to more gingival inflammation and periodontal bone loss. Therefore, patients must have a strict oral hygiene care and educated about the potential implications.