Background:The present study was conducted for assessing efficacy of laparoscopic cholecystectomy in comparison to open cholecystectomy. Materials & methods:A total of 200 Cholecystectomy patients were enrolled. Inclusion criteria for the present study included 200 patients undergoing cholecystectomy for symptomatic cholecystitis due to cholelithiasis irrespective of age or gender. These patients were evaluated in the hospital and after evaluation are put in two groups based on open cholecystectomy and laparoscopic cholecystectomy. These patients were followed for a period of 6 months after discharge for any complications. All the results were recorded in Microsoft excel sheet and were analyzed by SPSS software. Results:Mean intraoperative blood loss among the patients of the LC group and OC group was 89.13 ml and 123.1 ml respectively. Significant results were obtained while comparing the mean intraoperative blood loss among the patients of the LC group and OC group. Mean duration of postoperative pain among patients of LC group was 14.3 hours and was significantly lower in comparison to the patients of the OC group (23.1 hours). While comparing statistically, it was seen that incidence of postoperative complications was significantly higher among the patients of the OC group. Conclusion:Laparoscopic cholecystectomy is an easy to perform, has low complication rates as compared to open cholecystectomy.