Background: Solitary thyroid nodule is defined clinically as the localised thyroid enlargement with apparently normal rest of the gland. The present study was conducted to assess the accuracy of Fine Needle Aspiration Cytology of solitary thyroid nodule. Material &Methods: This descriptive study was conducted to assess the accuracy of Fine Needle Aspiration Cytology of solitary thyroid nodule over a period of 6 months. It included 50 cases of solid solitary thyroid nodule fulfilling inclusion criteria. A detailed history was taken and the patient was thoroughly examined. Fine needle aspiration cytology was performed. The statistical analysis was performed using the statistical program for social sciences (SPSS). Results: In this study FNAC of solitary thyroid nodule revealed that 62.83% were nodular goitre, 28.57% were benign cyst among benign lesions and 8.57% were Lymphocytic thyroiditis while 53.33% were follicular carcinoma, 33.33% were papillary carcinoma and 6.66% were Hurthle cell lesion and suspicious of neoplasm respectively. In our study histopathological findings of Solitary colloid nodule were as 71.87%, 21.87% benign thyroid cyst while 50% were follicular adenoma, 22.22% were colloid adenoma. In our study 10% were false negative, 14% were false positive, 36% true negative and 40% cases were true positive. Conclusion: The present study concluded that FNAC of solitary thyroid nodule revealed 40% cases were true positive on comparing histopathologically.