Background: Following a sternotomy, chest tube insertion, and subsequent leg vein incisions, patients undergoing heart surgery may experience pain in the surrounding areas. The present study was conducted to assess the effectiveness of oral paracetamol-based post-operative analgesia for adult post-cardiac surgery patients post-extubation in the ICU. Materials &Methods: 120 adult patients undergoing Off-Pump Coronary Artery Bypass Grafting (CABG) surgery of both genderswere divided into 2 groups. When the patients in group I were on a ventilator and sponged the following morning at approximately five in the morning, two 250 mg suppositories of Paracetamol were given to them. Group II patients were given placebos. Pain control was assessed in all patients using a Numeric Rating Scale (NRS) of 0 to 10. Results:The mean weight was 70.4 kgs in group I and 75.8 kgs in group II. The mean height was 172.7 cm in group I and 178.5 cm in group II. The ejection fraction was 63.4 in group I and 61.2 in group II. Cardiopulmonary bypass time was 116.8 minutes in group I and 113.5 minutes in group II. The duration of anesthesia was 312.4 minutes in group I and 328.6 minutes in group II. Aortic cross-clamp time was 90.2 minutes in group I and 88.1 minutes in group II and extubation time was 4.3 hours in group I and 5.2 hours in group II. The difference was non- significant (P> 0.05). The mean pain score (VAS) at 12 hours was 3.7 in group I and 6 in group II, at 24 hours was 2.5 in group I and 5.2 in group II, at 48 hours was 1.9 in group I and 3.5 in group II and at 72 hours was 1.3 in group I and 2.2 in group II. The difference was significant (P< 0.05). Morphine consumption was 55.4 mg in group I and 92.2 mg in group II. Rescue doses of morphine were needed in 13.4 patients in group I and 25.3 patients in group II and PONV was seen in 7.5 in group I and 2.4 in group II. The difference was significant (P< 0.05). Conclusion:The analgesic effects were excellent, and the patients felt at ease using the procedure. This straightforward post-operative analgesic treatment is very affordable, easy to follow, and has no significant adverse effects.