Background: Recurrent pregnancy loss is a frequently unexplained condition which affects 1–3% of couples who are trying to have children. Present study aimed to examine relationship between psychological stress and Recurrent Pregnancy Loss. Materials and method: A total of 40 couples who had experienced at least two consecutive miscarriages were recruited by means of convenience sampling. The inclusion criteria are abortions that must be 2 or more in number and spontaneous.The socio demographic details of patients were assessed using a semi structured questionnaire. The other related history which includes parity, gestational week duration following abortions, duration of marriage and other bad obstetric history were also inquired. The history of previous pregnancy complications was also recorded. Emotional distress such as depressive cognition, anxiety features, stress, sleep disturbances among the couples were analyzed using HAM-A and HAM-D scales. Results: Females experience more perceived stress than their counterparts. Females and males significantly differ on the dimensions of appraisal support (t (78) = 10.62, p < 0.01, belonging support (t (78) = 10.70, p < 0.01, esteem support (t (78) = 9.64, p < 0.01 and tangible support (t (78) = 10.56, p < 0.01). Observation from the table states that the mean score of females (X ̅ = 41.25) on anxiety is high than males (X ̅ = 23.48). Further stated that the mean score of females (X ̅ = 18.98) on depression is high than males (X ̅ = .75).those couples having high appraisal support and belonging support are low on stress. Those couples having high depression are having high stress. Conclusion: Depression, anxiety, and post-traumatic stress disorder are the most common psychological disorders seen among couples with recurrent pregnancy loss. Also due to these comorbidities the relationship among couples gets impaired which further have a negative impact on quality of life leading to a negative outcome in future conceptions. While prescribing them pharmaco-therapeutic treatment, risks-benefit ratio should always be kept in mind.