Background-The enhanced recovery after surgery (ERAS) group presenting a comprehensive study of perioperative care for colorectal surgery / colorectal resection is a set of interventions, when combined, lead to early return of gut function, fewer complications and a shorter length of stay. Traditional hospital stay of 10 - 14 days following major bowel resection had been accepted as normal practice up until recently. Aim-To study the impact of multimodal perioperative management protocol in patients of colorectal cancer surgery. Objective-To measure the outcomes such as hospital stay, complication, 30 days readmission rate in multimodal and control group. Material and methods- Study design-Prospective randomized control study. Sample size-30 patients of Colorectal cancer. Statistical analysis-simple randomization by block method, unpaired t-test. Results-Out of 30 patients {n=14 in multimodal group and n=16 in control group}, hospital stay of 6.64+/-0.842(median 6-9) and 8.25+/-1.52.(median 6-12)days(p=0.002), complication rate of 13.40% and 20.31%(p=0.019), 30-days readmission rate of 14.28% and 25%(p=0.029) and mortality rate of 7.14% and 12.5% were noted respectively in multimodal and control groups. Conclusion- The use of multimodal perioperative management protocol in colorectal cancer reduced the hospital stay, complication rate, readmission rate and mortality significantly as compared to the control group.